目前,英国由于滥用药物而中毒住院的患者中,三环抗抑郁剂是最常用的药物,居过量用药致死的第二位(第一位是巴比妥酸盐类)。最近几年来,许多新的抗抑郁剂已应用于临床。其中许多品种与传统的三环类药物和单胺氧化酶抑制剂不同,对副交感神经和心脏的影响很小或没有影响。本文对米塞林和其他新抗抑郁剂的临床毒理学与传统的三环类化合物作一比较。三环类抗抑郁剂:过量用药对副交感神经、中枢神经、心脏及呼吸系统有影响。副交感神经系统的副作用包括口干、视力模糊、瞳孔扩大、便秘、尿潴留及发热。这些并发 At present, tricyclic antidepressants are the most commonly used drugs among those hospitalized in the United Kingdom due to drug abuse and are the second leading cause of overdose (the first barbiturates). In recent years, many new antidepressants have been used clinically. Many of these varieties, unlike traditional tricyclic drugs and monoamine oxidase inhibitors, have little or no effect on parasympathetic nerves and the heart. This article compares the clinical toxicology of misexin with other new antidepressants with traditional tricyclic compounds. Tricyclic antidepressants: Overdose affects parasympathetic nerves, central nervous system, heart and respiratory system. Side effects of the parasympathetic nervous system include dry mouth, blurred vision, dilated pupils, constipation, urinary retention, and fever. These concurrency