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目的探讨支气管激发试验联合激发前后血清TIgE检测对咳嗽变异型哮喘（CVA）诊断的特异性和敏感性。方法将咳嗽变异型哮喘与急性支气管炎和无支气管疾病的患者进行比较，分别进行检测FEV_1／FVC、支气管激发试验，以化学发光法分别检测每例患者支气管激发试验前后的TIgE水平。结果CVA组气道高反应性的阳性率为96．7％，显著高于急性支气管炎组和对照组。CVA患者激发前和激发后的TgE水平分别为（150.25±52．71）Ku／ L和（261．22±27.44）Ku／L，与急性支气管炎组和对照组比较差异均有显著性（P＜0．05）；TIgE的阳性率比较差异亦有显著性（P＜0．05）。结论对怀疑有咳嗽变异型哮喘的病人同时行气道高反应性和TIgE水平检测，具有较高的诊断特异性。
Objective To investigate the specificity and sensitivity of serum TIgE in patients with cough variant asthma (CVA) before and after bronchial provocation test. Methods Cough variant asthma was compared with patients with acute bronchitis and without bronchial disease. FEV 1 / FVC and bronchial provocation test were performed respectively. The levels of TIgE in each patient before and after bronchial provocation test were detected by chemiluminescence. Results The positive rate of airway hyperresponsiveness was 96.7% in CVA group, which was significantly higher than that in acute bronchitis group and control group. The TgE levels before and after challenge in CVA patients were (150.25 ± 52.71) Ku / L and (261.22 ± 27.44) Ku / L, respectively, which were significantly different from those in acute bronchitis group and control group <0.05). The positive rate of TIgE was also significantly different (P <0.05). Conclusion Patients with suspected cough variant asthma with high airway hyperresponsiveness and TIgE levels have high diagnostic specificity.