论文部分内容阅读
目的 研究大鼠吡罗昔康局部给药的药物传递和机理。方法 大鼠分别局部给药和口服 4mg吡罗昔康后 ,用HPLC法测定局部给药部位的皮肤、肌肉、关节和血液的药物浓度。结果 口服给药后 ,Tjoint Plasma和Tmus Plasma比值保持恒定 ,大部分的时间其值介于 0 0 6和 0 2。比较而言 ,局部给药后 ,Tjoint Plasma和Tmus Plasma比值分别介于 0 2到 1 2 6和 1 89到5 4之间。比值远远大于口服给药。结论 数据表明局部给药后 ,到达局部深层组织的吡罗昔康来自于药物的直接渗透 ;当药物的靶向部位在局部时局部给药优于口服给药。
Objective To study the drug delivery and mechanism of local administration of piroxicam in rats. Methods After local administration and oral administration of 4 mg of piroxicam respectively, the drug concentrations in the skin, muscle, joints and blood of the local administration sites were determined by HPLC. Results After oral administration, the Tjoint Plasma and Tmus Plasma ratios remained constant, with values for most of the time between 0 0 6 and 0 2. In comparison, the Tjoint Plasma and Tmus Plasma ratios ranged from 0 2 to 1 26 and 1 89 to 54, respectively, after topical administration. Ratio is much larger than oral administration. Conclusions The data indicate that piroxicam to local deep tissue comes from direct penetration of the drug after topical administration; local administration of the drug at a localized site is superior to oral administration.