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甲胎蛋白(AFP)是肝细胞癌血清学诊断的一项有价值的指标,但在有些肝细胞癌病人中并不增高。所以必需寻找具有高敏感性和特异性的一些新的肿瘤指标。本文报告343例肝病病人血清铁蛋白测定的结果,以估价其对肝细胞癌诊断的临床意义。343例受检者中肝炎24例,肝硬化150例,肝癌132例,转移性肝癌37例,正常人35例。采用放射免疫测定技术检查空腹时血清铁蛋白。同时测定AFP。几乎全部病人亦测定了SGOT,SGPT,血清铁。结果肝病中的血清铁蛋白水平:正常人血清铁蛋白水平男性为59±11ng/ml,女性27±6ng/ml。肝硬化为168±14ng/ml,肝癌423±37ng/ml,转移性肝癌441±143ng/ml,肝炎病人最高,为969±326ng/ml,与SGOT和SGPT有明显的相关
Alpha-fetoprotein (AFP) is a valuable indicator of serological diagnosis of hepatocellular carcinoma, but it does not increase in some patients with hepatocellular carcinoma. Therefore, it is necessary to find some new tumor markers with high sensitivity and specificity. This article reports the results of serum ferritin determination in 343 patients with liver disease to evaluate its clinical significance for the diagnosis of hepatocellular carcinoma. Of the 343 subjects, 24 were hepatitis, 150 were liver cirrhosis, 132 were liver cancer, 37 were metastatic liver cancer, and 35 were normal. Radioimmunoassay techniques were used to examine fasting serum ferritin. Simultaneous determination of AFP. Almost all patients also measured SGOT, SGPT, serum iron. Results Serum ferritin levels in liver disease: Normal human serum ferritin levels were 59±11 ng/ml for men and 27±6 ng/ml for women. Liver cirrhosis was 168±14 ng/ml, liver cancer was 423±37 ng/ml, metastatic liver cancer was 441±143 ng/ml, hepatitis was the highest, and it was 969±326 ng/ml. It was significantly correlated with SGOT and SGPT.