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REIC基因在永生化的细胞系和部分肿瘤细胞系中发现并且表达下调,在许多人的肿瘤组织中表达也减少.目前研究认为,REIC/Dkk-3表达下调可能与启动子的甲基化有关.异常REIC/Dkk-3表达所致细胞表型异常在恶性肿瘤发生和演进过程中发挥重要作用.细胞浆型和分泌型REIC与靶蛋白作用后启动细胞信号传导,但是REIC/Dkk-3的生物学功能尚未深入阐述.对REIC/Dkk-3的研究在理论上可以大大推动肿瘤病因学的发展,为肿瘤的诊断和治疗提供一个新的分子靶点,对提高肿瘤患者生存率和生存质量具有很大的促进作用.如果能研发REIC/Dkk-3抗肿瘤重组多肽及增强REIC/Dkk-3作用的化疗药物,也将为肿瘤患者治疗开辟新的途径和思路.本文就REIC/Dkk-3蛋白在肿瘤发生发展中作用进行综述.
REIC gene was found in immortalized cell lines and some tumor cell lines and downregulated in many human tumor tissues also reduced the current study suggests that REIC / Dkk-3 downregulation may be related to the promoter methylation Abnormal cell phenotype induced by abnormal REIC / Dkk-3 expression plays an important role in carcinogenesis and progression of malignant tumor.Cell-plasma and secretory REIC activate cell signaling after interacting with target protein, but REIC / Dkk-3 Biological function has not been elaborated.Research on REIC / Dkk-3 can greatly promote the development of tumor etiology in theory, provide a new molecular target for the diagnosis and treatment of tumors, and improve the survival rate and quality of life of tumor patients Will greatly promote the treatment of cancer patients.If we can develop REIC / Dkk-3 anti-tumor recombinant peptides and enhance the effect of REIC / Dkk-3 chemotherapy drugs, it will open up new avenues and ideas for the treatment of cancer patients.This article REIC / Dkk- 3 protein in tumor development and development are reviewed.