Rapid growth in biomedical research coupled with dramatic advancement in biotechnology has signi fi cantly improved our understanding of the molecular basis involving cancer development and progression. This improvement has led to the discovery of new molecular markers for cancer diagnosis and prognosis as well as new molecular targets for cancer treatment and intervention. Continuous emergence of some new developing area in molecular profi ling, new therapeutic agents, tissue microenvironment and systems biology have made signifi cant progress in clinical oncology. Clinical research and investi-gation that focus on these new developments have begun to show exciting results that indicate future promises in improving patient management and survival. Rapid growth in biomedical research coupled with dramatic advancement in biotechnology has signi fi cantly improved our understanding of the molecular basis involving cancer development and progression. This improvement has led to the discovery of new molecular markers for cancer diagnosis and prognosis as well new molecular targets for cancer treatment and intervention. Continuous emergence of some new developing area in molecular profi ling, new therapeutic agents, tissue microenvironment and systems biology have made signifi cant progress in clinical oncology. Clinical research and investi-gation that focus on these new developments have begun to show exciting results that indicates future promises in qualifying patient management and survival.