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许多实验证实:氨基酸神经递质,特别是r-氨基丁酸(GABA)与惊厥的机制有关。但是,对癫痫患者脑或CSF GABA水平的临床研究是有争论的。本文研究了31例不同类型儿童癫痫的腰穿CSFGABA水平和抗痉药治疗的影响。其中女17例、男14例。年龄2月～12岁。部分性发作11例、婴儿痉挛9例、肌阵挛发作4例、强直-阵挛发作4例、其它发作3例。并与41名年龄相仿的无神经系统疾患的儿童作对照,其中女20名、男21名。全部患者腰穿取脑脊液,先排掉2～3ml后,留取1.5ml作GABA分析,结果如下: CSF GABA平均水平对照组41名儿童为174(95～316)pmol/ml,与性别和年龄无明显关系。31例癫痫儿童为141(68～294)pmol/ml,与对照
Numerous experiments have confirmed that amino acid neurotransmitters, especially r-aminobutyric acid (GABA), are involved in the mechanism of convulsions. However, clinical studies of brain or CSF GABA levels in patients with epilepsy are controversial. This article studies the effects of lumbar puncture CSFGABA levels and antispasmodic treatment on 31 different types of children with epilepsy. Among them, 17 were women and 14 were males. Age from February to 12 years old. 11 cases of partial seizures, 9 cases of infantile spasms, 4 cases of myoclonic seizures, 4 cases of tonic-clonic seizures and 3 cases of other seizures. And compared with 41 children of similar age without neurological disorders, 20 women and 21 males. All patients received cerebrospinal fluid lumbar lumbar puncture. After removing 2 to 3 ml of the cerebrospinal fluid, 1.5 ml of GABA was collected and analyzed. The results were as follows: Average level of CSF GABA 41 children (95-316) pmol / ml in control group, No obvious relationship. Thirty-one children with epilepsy were 141 (68-294) pmol / ml, compared with controls