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目的探讨充血性心力衰竭(CHF)患者B型钠尿肽(BNP)的水平变化及其与心功能变化的关系。方法采用化学发光微粒子酶免疫分析法检测2011年1月至2012年1月本院住院的60例充血性心力衰竭患者和30例健康对照者B型钠尿钠肽的水平。结果充血性心力衰竭患者B型钠尿肽的水平明显高于健康对照者,两组比较差异具有统计学意(P<0.05);充血性心力衰竭患者BNP浓度随着心功能分级的增高而升高(P<0.05),BNP与心功能分级呈正相关(r=0.895,P<0.01)。结论充血性心力衰竭患者BNP明显升高,能够敏感的反应心力衰竭患者心功能的改变,可作为诊断心力衰竭、准确的评价心功能、治疗效果的客观指标。
Objective To investigate the changes of B-type natriuretic peptide (BNP) and its relationship with cardiac function in patients with congestive heart failure (CHF). Methods The levels of B-type natriuretic peptide in 60 congestive heart failure patients and 30 healthy controls hospitalized in our hospital from January 2011 to January 2012 were detected by chemiluminescence microparticle enzyme immunoassay. Results The levels of B-type natriuretic peptide in patients with congestive heart failure were significantly higher than those in healthy controls (P <0.05). BNP levels in patients with congestive heart failure increased with the increase of cardiac function (P <0.05). There was a positive correlation between BNP and heart function (r = 0.895, P <0.01). Conclusion The BNP level in patients with congestive heart failure is significantly higher than that in patients with congestive heart failure. The changes of cardiac function in patients with congestive heart failure can be used as objective indicators to diagnose heart failure and accurately evaluate cardiac function and therapeutic effect.