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HSP70作为热休克蛋白家族中最重要一类,具有分子伴侣作用,并在抗原递呈、交叉递呈、激活淋巴细胞、自然杀伤细胞、巨噬细胞以及诱导树突状细胞成熟中发挥重要作用,参与机体特异性免疫和固有免疫,在胃癌组织中高表达。HSP70可能通过与多种原癌基因和抑癌基因及其蛋白产物相互作用从而调节肿瘤细胞的增殖。HSP70增高与胃癌发生、发展及浸润与淋巴结转移有密切关系。利用HSP70的反义基因可以抑制HSP70在胃癌组织的高表达,对阻碍胃癌的发生具有重要的作用。
As the most important class of HSPs, HSP70 plays a chaperone role and plays an important role in antigen presentation, cross presentation, activation of lymphocytes, natural killer cells, macrophages, and induction of dendritic cell maturation. Involved in body-specific immunity and innate immunity, high expression in gastric cancer. HSP70 may regulate tumor cell proliferation by interacting with a variety of proto-oncogenes and tumor suppressor genes and their protein products. HSP70 increased with the occurrence of gastric cancer, development and invasion and lymph node metastasis are closely related. The use of antisense HSP70 gene can inhibit the high expression of HSP70 in gastric cancer, hinder the occurrence of gastric cancer has an important role.