用４－硝基喹啉氧化物诱发Ｗｉｓｔａｒ大鼠聘粘膜癌，动态观察致癌物诱癌过程的超微结构变化。结果发现，由癌前病变、原位癌发展为鳞癌，细胞的超微结构出现渐进性变化。资料表明，核形态不规则，染色质边集，核膜增厚，线粒体及核糖体增多是癌前病变的超微结构特征；胞浆内桥粒是癌变的重要特征之一。 Using 4-nitroquinoline oxide to induce mucosal cancer in Wistar rats, and dynamically observe the ultrastructural changes of the carcinogen-induced cancer. As a result, it was found that from the precancerous and in situ carcinomas to squamous cell carcinoma, the ultrastructure of the cells gradually changed. The data show that the irregular nuclear morphology, chromatin edge collection, nuclear membrane thickening, and increased mitochondria and ribosomes are the ultrastructural features of precancerous lesions; cytoplasmic desmosomes are one of the most important features of carcinogenesis.