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有丝分裂灾难是一种由异常有丝分裂引起的细胞死亡现象.近年来,靶向诱导肿瘤细胞发生有丝分裂灾难药物的基础和开发研究越来越受到关注,现有药物诱导肿瘤细胞发生有丝分裂灾难死亡的作用和机制研究也取得了积极进展.本文将靶向诱导肿瘤细胞发生有丝分裂灾难的药物及其作用机制研究的最新进展进行分类探讨,为新型有丝分裂灾难诱导剂的开发应用提供参考依据.“,”Mitosis catastrophe is a phenomenon of cell death caused by abnormal mitosis.In recent years,more and more attention has been paid to the basic and developmental research of mitosis catastrophe targeted medicines on tumor cells,and the research on the mechanism about tumor death of mitotic catastrophe induced by existing drug has also made positive progress.In this paper,we will discuss the latest progress on the mitosis catastrophe targeted medicines on tumor cells and its mechanism,to provide references for the development and application of new mitotic catastrophe inducer.