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目的探讨辅酶Q10治疗急性有机磷中毒心肌损伤的临床疗效。方法选取2010年1月至2013年12月萧县第二人民医院收治的65例急性有机磷中毒患者,随机分为两组,对照组30例进行综合治疗;治疗组35例在综合治疗的基础上,应用辅酶Q10,对比两组患者的临床疗效。结果两组患者血清心肌酶均明显升高,治疗后两组患者血清心肌酶均下降,其中,治疗组下降更明显,恢复更快。治疗组疗效明显优于对照组,两组比较差异有统计学意义(P<0.05)。结论辅酶Q10对急性有机磷中毒心肌损伤起保护作用。
Objective To investigate the clinical efficacy of coenzyme Q10 in the treatment of myocardial injury caused by acute organophosphate poisoning. Methods Sixty-five patients with acute organophosphate poisoning admitted to the Second People’s Hospital of Xiaoxian County from January 2010 to December 2013 were randomly divided into two groups, the control group of 30 patients were treated with comprehensive treatment; the treatment group of 35 patients in the basis of comprehensive treatment On the application of coenzyme Q10, compared the clinical efficacy of two groups of patients. Results Serum myocardial enzymes were significantly increased in both groups. After treatment, the levels of serum myocardial enzymes decreased in both groups. The treatment group decreased more obviously and recovered faster. The treatment group was significantly better than the control group, the difference between the two groups was statistically significant (P <0.05). Conclusions Coenzyme Q10 can protect myocardium from acute organophosphate poisoning.