药物血浓度的测定是发展药物代谢动力学(下称药物动力学),生物药剂学及临床用药监护的基础。十多年来有关文献报道数以千计,写成的综述及专著也有几十篇。随着这些新兴学科的发展,也促进了方法学的发展。本文对此作一些概括的介绍。测定药物血浓度的意义药物血浓度是指给药后未经分解或代谢的原药在血浆或血清中的浓度,它包括游离原药和与血清白蛋白相结合的原药两部分。个别药物的血浓度测定早在 Determination of drug blood concentration is the basis for the development of pharmacokinetics (hereinafter referred to as pharmacokinetics), biological pharmacy and clinical drug monitoring. Over the past decade, there have been thousands of reports in the literature, dozens of articles and monographs. With the development of these emerging disciplines, the development of methodology has also been promoted. This article gives some general introduction. Significance of determination of drug blood concentration Drug blood concentration refers to the concentration of the drug in the plasma or serum after administration without any decomposition or metabolism, which includes the free drug and the original drug combined with serum albumin. Blood concentration of individual drugs as early as