乙氨芴酮是一种小分子干扰素诱导剂,1977年我们发现该药对实验性动物矽肺有明显疗效,为子过渡到临床应用,本文对该药的急慢性毒性进行研究。Wamplei对15名肿瘤患者进行该药治疗,除恶心、纳差外无其他不适,各内脏功能测定均属正常。Renton报道大白鼠灌胃投入乙氨芴酮后血清蛋白有降低。Sowinski报道乙氨芴酮能导致实验动物脾、淋巴结胸腺依赖区T淋巴细胞衰退、大白鼠脉络膜丛上皮细胞空泡变性。因国 Ethafluorenone is a small molecule interferon inducer. In 1977, we found that the drug has obvious curative effect on experimental animal silicosis, which is a transitional to clinical application. The acute and chronic toxicity of this drug is studied in this paper. Wamplei 15 patients with cancer treatment of the drug, in addition to nausea, anorexia no other discomfort, the determination of the internal organs were normal. Renton reports a decrease in serum albumin levels after intragastric administration of baflufenone in rats. Sowinski reported that baflunone induced degeneration of T lymphocytes in the spleen, lymph node thymus-dependent region, and degeneration of choroid plexus epithelium in rats. Because of the country