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经溶剂/去污剂处理而制备的高纯度因子Ⅷ和因子Ⅸ浓缩剂仍有污染非包膜病毒的危险。本文报道了最终干热处理对这类制剂及非包膜病毒〔甲型肝炎病毒（HAV）和犬细小病毒（CPV）〕的影响。 HAV HM175 18F株和野生型CPV分别以6.3～7.3放免灶形成单位（RFU）/ml和4.2半数组织培养感染量（TCID_(50)）的滴度稀释10倍后加到凝血因子浓缩剂中。HAV的感染性以放免灶测定法或ELISA法测定,最
High purity Factor VIII and Factor IX concentrates prepared by solvent / detergent treatment are still at risk of contaminating non-enveloped viruses. This paper reports the effects of final dry heat treatment on these preparations and non-enveloped viruses [Hepatitis A (HAV) and Canine Parvovirus (CPV)]. The HAV HM175 18F strain and the wild-type CPV were added to the clotting factor concentrate at a titer of 6.3 to 7.3 for radioimmunohistolysis units (RFU) / ml and 4.2 half of the tissue culture infection (TCID_ (50)), respectively. The infectivity of HAV was determined by radioimmunoassay or ELISA