利用相转移催化剂促进Reimer-Tiemann反应合成2-羟基-1-萘甲醛,系统的研究了原料配比、反应时间、反应温度,不同的相转移催化剂对Reimer-Tiemann反应的影响。研究结果表明:利用水浴加热,以无水乙醇作溶剂,碱性介质中,氯仿过量2—3倍,反应温度设置为75—80℃,2-羟基-1-萘甲醛的产率可达到45%—50%,利用相转移催化剂合成与传统合成方法相比显著缩短了反应时间,产率有所增加。 The phase transfer catalyst was used to promote the Reimer-Tiemann reaction to synthesize 2-hydroxy-1-naphthaldehyde. The effects of the ratio of raw materials, reaction time, reaction temperature and different phase transfer catalysts on the Reimer-Tiemann reaction were systematically investigated. The results show that the yield of 2-hydroxy-1-naphthaldehyde can reach 45 by using water-bath heating with anhydrous ethanol as the solvent and 2-3 times as much chloroform in alkaline medium as the reaction temperature is set at 75-80 ℃. % -50%, the use of phase transfer catalyst synthesis compared with the traditional synthesis method significantly shortens the reaction time, the yield increased.