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细胞姐妹染色单体交换 (SCE)频率的改变能真实地反映出DNA损害和/或修复,其灵敏性(或出现率)超过染色体或染色单体断裂二百倍,所以自1957年发现其观察方法以来逐渐已成为检测致变剂、致畸剂和致癌剂的细胞遗传学效应的一种新的重要技术。近年来又发现了一些有并发恶性肿瘤倾向的染色体不稳定性综合征,例如Bloom氏综合征,病人体细胞的SCE成倍地多于正常人~1。因此,国内外学者在SCE与恶性肿瘤的关联方面也作了许多研究。虽然,到目前为止,尚未观察到周围血淋巴细胞SCE频率增加肯定地导致了遗传缺陷或产生一种
Changes in the frequency of sister chromatid exchanges (SCEs) of cells can truly reflect DNA damage and/or repair. Their sensitivity (or appearance rate) exceeds that of chromosomes or chromatids by 200-fold, so their observations were observed since 1957. Since the method has gradually become a new important technology for the detection of cytogenetic effects of mutagens, teratogens and carcinogens. In recent years, a number of chromosomal instability syndromes have been discovered that have a tendency toward concurrent malignancies, such as Bloom’s syndrome, in which the SCE of the patient’s somatic cells has more than doubled that of a normal person. Therefore, many scholars at home and abroad have also done a lot of research on the relationship between SCE and malignant tumors. Although, so far, no increase in SCE frequency of peripheral blood lymphocytes has been observed to positively cause genetic defects or produce a