论文部分内容阅读
目的检测2型糖尿病患者前臂皮肤微循环改变并探讨其与糖尿病病程的关系。方法选择2型糖尿病患者37例,其中短病程组(病程≤5年)20例,长病程组(病程≥15年)17例,同时选取正常对照组30例。用皮肤血流阻断后反应性充血(PORH)的方法,以左前臂皮肤为测定点,应用激光多普勒血流仪(LDF)记录阻断前、中、后的皮肤微血流值。结果短病程组的皮肤微血流最大值(PUm ax)明显高于长病程组(28.90±9.00比20.35±7.28,P<0.01);短病程组的皮肤微血管反应性充血速率明显大于长病程组(2.63±1.44比1.68±0.89,P<0.01)。而正常对照组与短病程组间无显著性差异(P>0.05)。相关分析中,PUm ax及充血速率均与DM病程呈负相关(r分别为-0.506,-0.443,P<0.01)。结论2型糖尿病患者前臂皮肤微血管病变随糖尿病病程延长而加重。
Objective To investigate the changes of forearm skin microcirculation in type 2 diabetic patients and to explore its relationship with the course of diabetes mellitus. Methods Twenty-seven patients with type 2 diabetes mellitus were selected, including 20 patients with short course of disease (≤ 5 years), 17 patients with long course of disease (≥ 15 years), and 30 normal controls. The method of blocking reactive hyperemia after cutaneous blood flow (PORH) was used to measure the microderma of frontal, middle and posterior skin by using laser Doppler flowmeter (LDF) to record the left forearm skin. Results The maximal skin microvascular flow (PUm ax) in short course group was significantly higher than that in long course group (28.90 ± 9.00 vs 20.35 ± 7.28, P <0.01). The rate of microvascular reperfusion in short course group was significantly longer than that in long course group (2.63 ± 1.44 vs 1.68 ± 0.89, P <0.01). There was no significant difference between normal control group and short course of disease (P> 0.05). In the correlation analysis, PUm ax and congestion rate were negatively correlated with DM course (r = -0.506, -0.443, P <0.01 respectively). Conclusion The forearm skin microangiopathy in type 2 diabetic patients aggravates with the prolongation of diabetes.