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目的探讨女性生殖生育因素与系统性红斑狼疮(SLE)发病的关系,为SLE的病因学研究及一级预防提供理论依据。方法采用病例对照的方法,选取天津医科大学总医院感染免疫科的121例SLE患者及在妇科就诊的非SLE患者122例作为对照。调查SLE患者及对照者的一般资料、月经生育情况等。采用单因素和多因素非条件Lo-gistic回归分析对SLE危险因素进行分析。结果单因素非条件Logistic回归分析结果显示,流产手术〔OR=7.53,95%CI(3.09,18.36)〕、绝育手术〔OR=30.04,95%CI(3.88,232.92)〕、月经量〔OR=2.39,95%CI(1.12,5.16)〕、月经规律情况〔OR=4.05,95%CI(1.67,9.82)〕、出生时母亲的年龄〔OR=1.08,95%CI(1.02,1.15)〕、初潮年龄〔OR=0.67,95%CI(0.57,0.80)〕、绝经年龄〔OR=0.55,95%CI(0.42,0.71)〕与SLE的发病相关(P<0.05)。多因素非条件Logistic回归分析显示,流产手术〔OR=4.28,95%CI(1.55,11.79)〕、初潮年龄〔OR=0.68,95%CI(0.50,0.91)〕、绝经年龄〔OR=0.51,95%CI(0.39,0.67)〕、月经规律情况〔OR=2.88,95%CI(1.13,7.31)〕与SLE的发病相关。结论月经初潮与绝经年龄早,做过流产手术,月经不规律,均是SLE的危险因素,这些影响可能潜在于SLE的病因机制中。
Objective To investigate the relationship between female reproductive reproductive factors and the pathogenesis of systemic lupus erythematosus (SLE) and to provide a theoretical basis for the etiology and primary prevention of SLE. Methods A case-control study was conducted in 121 SLE patients and 122 non-SLE patients attending gynecology department of Tianjin Medical University General Hospital as control. SLE patients and controls surveyed the general information, menstrual fertility and so on. Univariate and multivariate non-conditional Lo-gistic regression analysis of risk factors for SLE. Results The results of univariate non-conditional Logistic regression analysis showed that the rates of abortion (OR = 7.53, 95% CI 3.09, 18.36), sterilization (OR = 30.04,95% CI 3.88,232.92) (OR = 4.05, 95% CI 1.67, 9.82), the age of the mother at birth (OR = 1.08, 95% CI 1.02, 1.15) Menopausal age [OR = 0.55, 95% CI (0.42, 0.71)] was associated with the onset of SLE (P <0.05). Multivariate non-conditional logistic regression analysis showed that the age of menopause [OR = 0.51, OR = 0.68, 95% CI (0.50, 0.91) 95% CI (0.39,0.67)〕, menstrual regularity (OR = 2.88,95% CI (1.13,7.31)〕 associated with the pathogenesis of SLE. Conclusions Menarche and early age of menopause are abortions and irregular menstruation, all of which are risk factors for SLE. These effects may be potentially involved in the pathogenesis of SLE.