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目的 探讨奥美拉唑对上腹部术中胃食管反流的预防效果。方法择期胆囊手术１５８例，随机分成Ａ组：于术前晚和术晨各口服奥美拉唑４０９ｍｇ；Ｂ组：加服西沙必利１０ｍｇ；Ｃ组：为对照组。用胃食管ＰＨ仪，分别测定术前胃内ｐＨ和连续监测术中食管下端ｐＨ值。结果 Ａ、Ｂ二组术前服药后胃内ｐＨ均值分别为 ５．１２±１．１３和５．４４±１．０２，术中食管下端ｐＨ无一人＜４．０，组间无明显差异，而Ｃ组术前胃内ｐＨ均值为１．９８±０．８２（Ｐ＜０．０１），术中食管下端ＰＨ＜４．０发生率为６３％（３３／５２）。结论术前口服奥美拉唑可明显提高胃内ｐＨ值，能起到预防或减少胃食管反流的效果。
Objective To investigate the preventive effect of omeprazole on gastroesophageal reflux during upper abdominal surgery. Methods Elective cholecystectomy in 158 patients were randomly divided into group A: omeprazole 409 mg orally in the night before surgery and morning; group B: plus cisapride 10 mg; group C: the control group. Gastroesophageal pH meter was used to measure the preoperative gastric pH and continuous monitoring of intraoperative esophageal pH value. Results The mean intragastric pH of group A and group B before operation was 5.12 ± 1.13 and 5.44 ± 1.02, respectively. There was no significant difference in pH between the two groups at the lower esophagus (<4.0) The average preoperative gastric pH value of group C was 1.98 ± 0.82 (P <0.01), and the incidence of PH <4.0 was 63% (33/52) during the operation. Conclusion Oral preoperative oral omeprazole can significantly increase the gastric pH, can play a preventive or reduce gastroesophageal reflux effect.