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目的:观察不同剂量戊酸雌二醇治疗宫腔镜术后宫腔粘连的临床效果。方法:选取2013年6月-2015年3月在我院接受宫腔镜手术且术后出现宫腔粘连的患者80例,根据用药剂量不同,将所选患者分为小剂量组和大剂量组,每组40例。小剂量组患者给予戊酸雌二醇3 mg,大剂量组患者给予戊酸雌二醇9 mg治疗。观察并比较两组患者的临床疗效、月经恢复情况及不良反应发生率。结果:大剂量戊酸雌二醇治疗宫腔粘连的临床疗效显著优于小剂量组,差异具有统计学意义(P<0.05)。大剂量戊酸雌二醇治疗宫腔粘连,患者术后的月经恢复率高于小剂量组,差异具有统计学意义(P<0.05)。两组不良反应的发生率比较,差异无统计学意义(P>0.05)。结论:9 mg戊酸雌二醇应用于宫腔镜术后具有较好的效果,能显著降低宫腔粘连发生率。
Objective: To observe the clinical effect of different doses of estradiol valerate on hysteroscopic uterine adhesions. Methods: Totally 80 patients who underwent hysteroscopic surgery and intrauterine adhesions in our hospital from June 2013 to March 2015 were selected. According to the different dosage, the patients were divided into low dose group and high dose group , 40 cases in each group. Patients in the low-dose group received estradiol valerate 3 mg and patients in the high-dose group received 9 mg estradiol valerate. The clinical efficacy, menstruation recovery and the incidence of adverse reactions were observed and compared between the two groups. Results: The clinical efficacy of high-dose estradiol valerate in treating intrauterine adhesions was significantly better than that of low-dose group (P <0.05). Large doses of estradiol valerate in the treatment of intrauterine adhesions, postoperative menstrual recovery rate was higher than the low-dose group, the difference was statistically significant (P <0.05). The incidence of adverse reactions in the two groups, the difference was not statistically significant (P> 0.05). Conclusion: The application of 9 mg estradiol valerate in hysteroscopy has a good effect and can significantly reduce the incidence of intrauterine adhesions.