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检测７２例慢性阻塞性肺部疾病（ＣＯＰＤ）患者及２６例正常人血、支气管肺泡泡洗液（ＢＡＬＦ）和肺泡巨噬细胞（ＡＭ）内ＣＡＭＰ和ｃＧＭＰ。结果表明：（１）正常人与ｃＯＰＤ患者外周血ｃＡＭＰ及ｃＧＭＰ无明显差异。（２）慢性支气管炎患者支气管及肺泡灌洗液中ｃＡＭＰ／ｃＧＭＰ明显降低，（３）皮质激素较舒喘灵更能改善ｃｏＰＤ患者ＡＭ内ｃＡＭＰ／ｃＧＭＰ水平。
72 patients with chronic obstructive pulmonary disease (COPD) and 26 normal human blood, bronchoalveolar lavage fluid (BALF) and alveolar macrophage (AM) were assayed for CAMP and cGMP. The results showed that: (1) there was no significant difference between cAMP and cGMP in peripheral blood of normal people and cOPD patients. (2) cAMP / cGMP in bronchoalveolar lavage fluid and bronchoalveolar lavage fluid were significantly decreased in patients with chronic bronchitis; (3) corticosteroids were more effective than salbutamol in improving coAMP / cGMP levels in AM patients.