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目的评价骨髓移植联合肾移植、亲属活体肾移植、尸体肾移植的疗效。方法对比三类肾移植各48例术后三个月内排斥反应的发生率。结果尸体肾移植联合骨髓移植较之单一尸体肾移植的急性排斥反应发生率显著降低,与亲属供肾肾移植相比急性排斥反应发生率已无明显差别。结论肾移植联合骨髓移植能通过增加混合嵌合体形成,从而诱导受体免疫耐受,可以减少排斥反应的发生,延长移植肾存活时间。
Objective To evaluate the efficacy of bone marrow transplantation in combination with kidney transplantation, relative living donor kidney transplantation and cadaver kidney transplantation. Methods The incidence of rejection in each of the 48 cases of three kinds of renal transplantation within three months after operation was compared. Results The incidence of acute rejection in cadaveric kidney transplantation combined with bone marrow transplantation was significantly lower than that in single cadaveric renal transplantation. There was no significant difference in the incidence of acute rejection between renal transplantation and cadaveric kidney transplantation. Conclusion Kidney transplantation combined with bone marrow transplantation can increase the immune tolerance of recipient by increasing the formation of mixed chimerism, which can reduce the incidence of rejection and prolong the survival time of allograft.