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目的:探讨福辛普利与金纳多(银杏叶提取物)联用治疗早期糖尿病肾病(IDN)的安全性和有效性。方法:将68例IDN患者随机分为治疗组36例和对照组32例。两组均严格控制血压、血糖及口服福辛普利(商品名:蒙诺)10 mg/d。治疗组加用金纳多治疗,共4周。结果:治疗组尿微量白蛋白排泄率(UAER)较治疗前显著下降(P<0.05),且优于对照组(P<0.05)。两组各3例出现有轻度干咳,差异无统计学意义(P>0.05)。结论:金纳多联合福辛普利能有效治疗IDN,改善肾功能,无明显不良反应。
Objective: To investigate the safety and efficacy of fosinopril combined with Ginaton (Ginkgo biloba extract) in the treatment of early diabetic nephropathy (IDN). Methods: Sixty-eight patients with IDN were randomly divided into treatment group (36 cases) and control group (32 cases). Both groups were under strict control of blood pressure, blood glucose and oral fosinopril (brand name: Monopril) 10 mg / d. The treatment group plus Jinnao treatment, a total of 4 weeks. Results: The urinary albumin excretion rate (UAER) in the treatment group was significantly lower than that before treatment (P <0.05) and better than that in the control group (P <0.05). Three patients in each group had mild dry cough, the difference was not statistically significant (P> 0.05). Conclusion: Ginaton combined with fosinopril can effectively treat IDN, improve renal function, no obvious adverse reactions.