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目的研究高迁移率族蛋白B1(HMGB1)在慢性肾衰竭及并发感染患者腹水中的水平变化及其临床意义。方法采用ELISA法对35例临床腹水标本(其中慢性肾衰竭无并发症10例,肾衰竭并发肺炎12例,肾衰竭并发腹膜炎13例)进行HMGB1检测,同时检测所有研究对象血液中的CRP水平。结果肾衰竭并发腹膜炎(C)组腹水(渗出液)HMGB1水平明显高于慢性肾衰竭无并发症(A)组及肾衰并发肺炎(B)组(漏出液),差异有统计学意义(P<0.01),A组与B组腹水中HMGB1水平的差异无统计学意义;B组和C组血液中的CRP水平明显高于A组,差异有统计学意义(P<0.01),提示体内存在感染。结论腹水HMGB1检测对慢性肾衰竭患者腹水性质的鉴别有较好的临床意义,若联合血液CRP指标的检测对临床鉴别诊断慢性肾衰竭有无并发其他感染性疾病也具有一定意义。
Objective To study the changes and clinical significance of high mobility group box 1 protein (HMGB1) in ascites of patients with chronic renal failure and concurrent infection. Methods Serum level of CRP was measured in 35 ascites samples (including 10 cases without complications of chronic renal failure, 12 cases with pneumonia and 13 cases with renal failure and peritonitis) by ELISA. Results The level of HMGB1 in ascites (exudate) in patients with renal failure complicated with peritonitis was significantly higher than that in patients without complications of chronic renal failure (Group A) and in patients with pneumonia (Group B) P <0.01). There was no significant difference in the level of HMGB1 in ascites between group A and group B. The blood levels of CRP in group B and group C were significantly higher than those in group A (P <0.01) There is an infection. Conclusion The detection of ascites HMGB1 has a good clinical significance in the identification of ascites in patients with chronic renal failure. It is of great significance to detect the combined blood CRP for the differential diagnosis of chronic renal failure and other infectious diseases.