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目的：比较奥美拉唑与雷尼替丁治疗上消化道激光性溃疡疗效。方法：上消化道息肉２１１例经Ｎｄ：Ｙａｇ激光治疗引起溃疡，分成２组，奥美拉唑组１０７例［男性５７例，女性５０例；年龄４０ａ±ｓ８ａ（２３～６９ａ）］于激光治疗前１ｄ开始服奥美拉唑２０ｍｇ，ｑｄ，连服２ｗｋ，雷尼替丁组１０４例［男性６５例，女性３９例；年龄４６ａ±９ａ（２５～７１ａ）］于激光治疗前１ｄ开始服雷尼替丁０．１５ｇ，ｂｉｄ，连服２ｗｋ。各组激光性溃疡未愈合则继服药１ｗｋ。激光治疗后１ｍｏ内每周复查胃镜１次。结果：４ｗｋ总有效率１００％，奥美拉唑组１ｗｋ愈合率８５．０％，２ｗｋ愈合率９９．１％；雷尼替丁组分别为２５．０％，６６．３％，２组差别有非常显著意义（Ｐ＜０．０１）。结论：奥美拉唑为治疗上消化道激光性溃疡的有效药物
Objective: To compare the efficacy of omeprazole and ranitidine in the treatment of upper gastrointestinal tract laser ulcer. Methods: 211 cases of upper gastrointestinal polyps were treated with Nd: Yag laser to cause ulcer and divided into 2 groups. In the omeprazole group, there were 107 cases (57 males and 50 females; age 40a ± s8a (23 ~ 69a) Omeprazole 20 mg, qd, and even 2 wk were administered before 1d, and 104 ranitidine (male 65, female 39; age 46a ± 9a (25-71a)] were given ld Nitidine 0.15g, bid, and even served 2wk. Each group of laser ulcers did not heal followed by medication 1wk. Gastroscopy was repeated weekly for 1 month after laser treatment. Results: The total effective rate was 100% at 4wk, 85.0% at 1wk and 99.1% at 2wk in omeprazole group, and 25.0% and 66.3% at ranitidine group respectively There is a very significant (P <0.01). Conclusion: Omeprazole is an effective drug for the treatment of upper gastrointestinal laser ulcer