患者，女，６３岁，以往无药物过敏史。因慢性鼻窦炎，在家自服阿莫西林胶囊０．５ｇ，次日晨起眼睑及手足背轻度红肿。停用阿莫西林，未做任何处理。下午病情逐渐加重，自服息斯敏１０ｍｇ，第３天上述症状明显加重，面部及四肢红肿明显，睁眼困难，全身布满皮疹，高出皮肤， Patient, female, 63 years old, no past history of drug allergy. Because of chronic sinusitis, home-serving amoxicillin capsules 0.5g, the next day morning eyelid and hand and foot mild swelling. Amoxicillin disabled, without any treatment. In the afternoon, the patient’s condition gradually aggravated. Self-administered astemizole 10 mg, the above symptoms were obviously aggravated on the 3rd day, the facial and limbs were swollen obviously, eyes open, the whole body covered with skin rash,