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目的 前瞻性评价99mTc 甲氧基异丁基异腈 (99mTc MIBI)乳腺显像检测原发性乳癌和腋淋巴结转移的灵敏度和特异性。方法 84例经临床病理学检查可疑乳癌妇女 ,应用99mTc MIBI进行乳腺平面俯卧左、右侧位和仰卧前位显像 ,每一体位采集时间 5～ 8min。乳房和腋窝区域包括在采集视野内。切除的乳腺和腋淋巴结的病理检查均在乳腺显像后 10d内进行。结果 乳腺平面显像检测原发性乳癌的灵敏度为 90 2 % (4 6 / 5 1) ,特异性为93 93 % (31/ 33)。 5 1例乳腺癌中有 2 5例发生腋淋巴结转移 ,乳腺显像检测腋淋巴结转移的灵敏度为 84% (2 1/ 2 5 ) ,特异性为 88 46 % (2 3/ 2 6 )。结论 本组结果显示乳腺平面显像在检测原发性乳癌和腋淋巴结转移均具有较高的诊断准确性
Objective To prospectively evaluate the sensitivity and specificity of 99mTc methoxyisobutylisonitrile (99mTc MIBI) mammography in the detection of primary breast cancer and axillary lymph node metastases. Methods Eighty-four cases of suspicious breast cancer women were examined by clinicopathology. The 99mTc MIBI was performed on the left and right side of the breast and the supine anterior position. The time of each position was 5 to 8 minutes. The breast and armpit areas are included in the collection field of view. Pathological examinations of the resected breast and axillary lymph nodes were performed within 10 days after breast imaging. Results The sensitivity of mammography in the detection of primary breast cancer was 90 2 % (4 6 / 51) and the specificity was 93 93 % (31 / 33). Axillary lymph node metastasis occurred in 25 of 51 cases of breast cancer. The sensitivity of axillary lymph node metastasis was 84% (21/25) and the specificity was 88.4% (23/26). Conclusion The results of this group show that breast planar imaging has high diagnostic accuracy in detecting primary breast cancer and axillary lymph node metastasis.