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目的探讨环氧合酶2(COX2)与肿瘤的血管生成、转移、细胞增殖、病理类型、患者预后的关系,深入研究COX2选择性抑制剂对大肠肿瘤防治的作用机制。方法采用免疫组化方法检测大肠肿瘤中COX2、血管内皮生长因子(VEGF)、CD34、增殖细胞核抗原(PCNA)的表达情况。结果COX2和VEGF的表达在大肠癌均有显著增加,分别为78%和76%。大肠癌中COX2的表达与VEGF的表达相关。COX2阳性的大肠癌中微血管密度(MVD)是阴性肿瘤中的3.9倍,VEGF阳性的大肠癌中MVD是阴性肿瘤中的3.2倍。结论COX2和VEGF在肠道腺瘤和结直肠癌形成早期就已开始表达,并在腺瘤的增生、癌变,肿瘤的形成、生长和血管形成中起重要作用。
Objective To investigate the relationship between cyclooxygenase 2 (COX2) and tumor angiogenesis, metastasis, cell proliferation, pathological types and prognosis of patients. To study the mechanism of COX2 selective inhibitors on the prevention and treatment of colorectal cancer. Methods Immunohistochemistry was used to detect the expression of COX2, VEGF, CD34 and PCNA in colorectal tumors. Results The expressions of COX2 and VEGF were significantly increased in colorectal cancer with 78% and 76%, respectively. The expression of COX2 in colorectal cancer correlates with the expression of VEGF. The microvessel density (MVD) in COX2-positive colorectal cancer was 3.9 times that in negative tumors, and the MVD in VEGF-positive colorectal cancers was 3.2 times more than in negative tumors. Conclusions COX2 and VEGF began to express early in the development of intestinal adenoma and colorectal cancer and play an important role in the proliferation, carcinogenesis, tumor formation, growth and angiogenesis of adenoma.