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目的:观察益气复脉注射液治疗冠心病心力衰竭合并心绞痛的临床疗效。方法:将162例心力衰竭合并心绞痛的患者随机分为两组,对照组予消心痛、血管紧张素转换酶抑制剂(ACEI)及血管紧张素受体拮抗剂(ARB)类、β受体阻滞剂(β-RB)、阿司匹林、他汀类药物,间断服利尿剂常规治疗;治疗组在对照组的基础上加用益气复脉注射液静滴5.2 g.d-1,共10 d。结果:治疗组心绞痛症状改善总有效率为85.36%优于对照组(75.00%,P<0.05);心电图疗效亦优于对照组;两组治疗前后心功能、左心室射血分数(LVEF)、6 min步行距离均得到改善,但治疗组明显优于对照组(P<0.05)。结论:益气复脉注射液养阴生津,可改善心功能、提高活动耐量并缓解心绞痛,对缺血的心肌细胞有明显的保护作用。
Objective: To observe the clinical effect of Yiqi Fumai injection in treating patients with coronary heart disease complicated by heart failure and angina pectoris. Methods: A total of 162 patients with angina pectoris and angina pectoris were randomly divided into two groups. The patients in the control group were given heartache, angiotensin converting enzyme inhibitor (ACEI) and angiotensin receptor blocker (ARB) (Β-RB), aspirin, statin and intermittent diuretic were given to the patients in the treatment group. 5.2 gd-1 of Yiqi Fumai injection was added to the treatment group for 10 days on the basis of the control group. Results: The total effective rate of improvement of angina pectoris in treatment group was 85.36%, which was better than that in control group (75.00%, P <0.05). The electrocardiogram was superior to that of control group. Before and after treatment, heart function, left ventricular ejection fraction (LVEF) 6 min walking distance were improved, but the treatment group was significantly better than the control group (P <0.05). Conclusion: Yiqi Fumai Yin Yang Sheng Jin, can improve cardiac function, improve activity tolerance and relieve angina pectoris, has a significant protective effect on ischemic cardiomyocytes.