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作者用放射免疫方法，测定了24例窒息后新生儿（其中呼吸衰竭9例）和33例正常新生儿的血浆ET－1和TXB2（TXA2的稳定代谢产物）及6－K－PGF1α（PGI2的稳定代谢产物）水平，并作动态观察。结果提示，分娩应激、尤其是窒息使新生儿血浆ET－1、TXA2和PGI2水平显著升高，随着缺氧情况改善，3种血管活性物质不同程度下降．ET－1与PGI2，TXA2与PGI2之间均处于动态平衡。血浆ET－1升高的幅度与呼吸衰竭的程度成正相关，ET－1在缺氧性肺血管收缩中可能起着重要作用。
The authors used radioimmunoassay to determine the plasma concentrations of ET-1 and TXB2 (a stable metabolite of TXA2) and 6-K-PGF1α (PGI2) in 24 neonates with asphyxia (respiratory failure in 9) and 33 normal neonates Stable metabolites) levels, and for dynamic observation. The results suggest that labor stress, especially asphyxiation, significantly increased the levels of plasma ET-1, TXA2 and PGI2 in newborns. With hypoxia, the three vasoactive substances decreased to varying degrees. ET-1 and PGI2, TXA2 and PGI2 in between the dynamic balance. The magnitude of plasma ET-1 elevation is positively correlated with the degree of respiratory failure, and ET-1 may play an important role in hypoxic pulmonary vasoconstriction.