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目的 比较国产与进口、连用与隔日使用左旋门冬酰胺酶 (L ASP)副作用发生情况。方法 采用病例分析方法 ,比较国产与进口L ASP以及L ASP连用与隔日使用肝功能、血尿酸、血糖、凝血三项 (PT、APTT、TT)、血浆白蛋白、血清钙以及纤维蛋白原的变化 ,所需输注的纤维蛋白原量。结果 国产与进口L ASP相比 ,国产L ASP所需输注纤维蛋白量高于进口L ASP ,副作用发生率无统计学差异 ,连用与隔日使用无统计学差异。结论 ①除纤维蛋白原降低外 ,国产与进口L ASP具有同样安全性 ;②连续使用与隔日使用L ASP治疗急性淋巴细胞性白血病 (ALL)同样安全
Objective To compare the incidence of side effects of L-asparaginase (L ASP), domestic and imported, used in combination with the next day. Methods A case analysis method was used to compare the changes of domestic and imported L ASP, LPS and liver function, blood uric acid, blood glucose and blood coagulation (PT, APTT, TT), plasma albumin, serum calcium and fibrinogen , The amount of fibrin that needs to be infused. Results Compared with imported L ASP, the amount of fibrin infusion required for domestic L ASP was higher than that of imported L ASP. There was no significant difference in the incidence of side effects between the two groups. There was no significant difference between domestic and imported L ASP. Conclusions ① Except for fibrinogen reduction, domestic and imported L ASP have the same safety; ② Continuous use and LAC treatment of acute lymphoblastic leukemia (ALL) every other day are equally safe