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目的评估多相位ASL在颅脑疾病中的临床应用价值。方法 20例颅内病变患者,其中脑膜瘤8例,胶质瘤2例,胶质母细胞瘤1例,淋巴瘤1例,脑梗死6例,神经源性肿瘤1例,室管膜瘤1例。对患者行3.0MR常规T1WI、T2WI、FLAIR和病变部位8相位ASL扫描。计算第1、5、8相位病变部位相对脑血流量值(rCBF),对病变的灌注情况进行分析。结果出血性脑梗死病例早、中、晚期均表现为高灌注。常规扫描双侧枕叶未发现明显异常病例,ASL显示右侧枕叶出现低灌注。急性或亚急性梗死患者和脑软化患者三期均表现为低灌注。其余脑梗死患者不同时相高、低灌注情况均出现。脑肿瘤病例中,部分肿瘤早、中、晚期灌注状态一致,如胶质瘤和部分脑膜瘤病例。部分肿瘤不同时相显示不同的灌注状态。结论本研究表明评估脑内病变的灌注情况具有时间依赖性。多相位ASL对于早期诊断脑缺血性疾病,评估脑梗死后的再灌注有独特的优势。
Objective To evaluate the clinical value of multiphasic ASL in craniocerebral diseases. Methods Twenty patients with intracranial lesions, including 8 meningioma, 2 glioma, 1 glioma, 1 lymphoma, 6 cerebral infarction, 1 neurogenic tumor, 1 ependymoma example. Patients underwent 3.0 MR conventional T1WI, T2WI, FLAIR and lesion 8-phase ASL scan. The relative cerebral blood flow values (rCBF) of the first, fifth and eighth phase lesions were calculated and the perfusion of the lesions was analyzed. Results The cases of hemorrhagic cerebral infarction showed high, early, middle and late perfusion. Routine scanning of bilateral occipital lobes showed no significant abnormalities, ASL showed low right occipital lobe perfusion. Patients with acute or subacute infarcts and patients with brain softening three showed low perfusion. The remaining patients with cerebral infarction at different phases of high, low perfusion are seen. Some cases of brain tumors, early, middle and late perfusion consistent, such as gliomas and some cases of meningioma. Some tumors showed different perfusion state at different phases. Conclusions This study shows that time-dependent perfusion assessment of brain lesions is time-dependent. Multi-phase ASL For the early diagnosis of cerebral ischemic disease, to assess the reperfusion after cerebral infarction has a unique advantage.