本文报道1例心内膜炎血培养阴性患者,系由衣原体TWAR株所致。病例:患者男性,59岁。因主动脉瓣狭窄作过手术。主诉手足皮疹2月,不痒,夜间盗汗咳嗽带白痰。T:38.2℃,四肢及躯干见红斑性紫癜,表浅淋巴结轻度肿大。ESR93mm/h,肌酐211mmol/L,6次血及骨髓培养均阴性,冷球蛋白102mg/L,类风湿因子1∶1280,多克隆球蛋白增加,IgG39.5g/L,IgM4.19g/L,及IgA215 This article reports one case of endocarditis blood culture negative patients, caused by Chlamydia TWAR strain. Case: Male patient, 59 years old. Surgery due to aortic stenosis. Chief complaint hand-foot rash February, itch, night sweats cough with white sputum. T: 38.2 ℃, limbs and torso see erythema purpura, superficial lymph nodes slightly enlarged. ESR93mm / h, creatinine 211mmol / L, 6 blood and bone marrow culture were negative, cold globulin 102mg / L, rheumatoid factor 1:1280, polyclonal globulin increased, IgG39.5g / L, IgM4.19g / L, And IgA215