目的:制备氢化可的松双层包衣片,并考察其体内外释药情况。方法:制备含氢化可的松片芯,以壳聚糖作为包衣的内衣层,以ACRYL-EZE作为外衣层,在体外模拟消化道环境考察药物的释放,并进行家犬解剖考察体内药物释放情况。结果:该药片在胃内保持完整,在小肠不崩解,在结肠定位释放。结论:壳聚糖双层包衣片可作为结肠定位释药系统的药物载体。 Objective: To prepare hydrocortisone bilayer coated tablets and investigate the drug release in vitro and in vivo. Methods: The hydrocortisone core was prepared, chitosan was used as the undercoat layer, ACRYL-EZE was used as the coat layer to simulate the release of the drug in the digestive tract environment in vitro. Happening. Results: The tablets remained intact in the stomach, did not disintegrate in the small intestine, and were released in the colon. Conclusion: Chitosan double-coated tablets can be used as drug carrier for colon-specific drug delivery system.