相关识别理论(Associative Recognition Theory,ART)认为,纯抗原通过抗原受体所产生的信号是阴性信号(信号1)。大多数证据表明,在与相应配体结合后,抗原受体可转导阳性信号,并导致B细胞活化。目前ART信号1作用机制的基础尚缺乏实验支持,然而B细胞产生的抗体对B细胞却具有抑制作用,所以由分泌抗体所产生的负反馈 Associative Recognition Theory (ART) believes that the signal produced by a pure antigen through an antigen receptor is a negative signal (signal 1). Most evidence suggests that antigen receptors can transduce a positive signal after binding to the corresponding ligand and lead to B cell activation. At present, the basis of the mechanism of ART signaling 1 is still lack of experimental support, however, the antibodies produced by B cells have an inhibitory effect on B cells. Therefore, the negative feedback generated by the secretion of antibodies