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目的： 在动物体内验证茶多酚临床毒副反应及性质。方法： 以茶多酚２６ ｍｇ ／ （ｋｇ·ｄ） 、１２５ ｍｇ／ （ｋｇ·ｄ） 、６００ ｍｇ ／ （ｋｇ·ｄ） ， 给家犬连续口服１８０ ｄ， 观察用药期毒性反应及停药２１ ｄ 期间恢复情况。结果： ６００ ｍｇ／ （ｋｇ·ｄ） 剂量组用药初期动物活动明显增加， 兴奋性提高。上述症状在继续用药１０ ～２０ ｄ 后逐渐减轻并消失。该剂量组用药１２０ ｄ 后， 动物体重增长明显减慢（ Ｐ＜ ０－０５ 或Ｐ＜ ０－０１） ， １８０ ｄ 后病理检查显示肝肾轻度浊肿（ 停药２１ ｄ 后处死动物未见肝、肾病变） 。１２５ ｍｇ／ （ｋｇ·ｄ） 和２６ ｍｇ ／ （ｋｇ·ｄ） 剂量动物未见毒性反应。结论： 茶多酚对家犬无毒反应剂量大约为１２５ ｍｇ／ （ｋｇ·ｄ） 。
Objective: To verify the clinical toxicities and properties of tea polyphenols in animals. METHODS: The dogs were continuously given orally for 180 days with 26 mg/(kg·d), 125 mg/(kg·d) and 600 mg/(kg·d) of tea polyphenols. The toxicity during drug use and drug withdrawal were observed. d During the recovery. RESULTS: At the initial stage of drug administration, the activity of animals in the 600 mg/(kg·d) dose group significantly increased and the excitability increased. The above symptoms gradually decreased and disappeared after 10 to 20 days of continuous medication. After 120 days of administration in this dose group, the body weight of the animals was significantly slowed down (P<0-05 or P<0-01). After 180 days, pathological examination showed mild liver and kidney edema (no animals were sacrificed after 21 days of drug withdrawal. Liver and kidney disease). There was no toxic reaction in animals at doses of 125 mg/ (kg·d) and 26 mg/(kg·d). Conclusion: The non-toxicity response of tea polyphenols to domestic dogs is about 125 mg/(kg·d).