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按统一研究设计和方法，对水氟浓度和营养状况不同的６个地区和煤氟含量不同的４个地区环境氟水平及１２００多名４０～６０岁居民的膳食营养、总摄氟量、氟中毒等流行病学及生化指标进行了综合调查分析。结果显示：高氟和营养不足地区的氟中毒检出率显著高于总摄氟量相近而营养正常地区，证实人体营养状况特别是钙与蛋白质对氟化物吸收利用确有一定影响。调查发现：摄入过量氟可能使体内清除自由基的能力降低；在相同氟水平下，营养正常人群血浆过氧化物歧化酶和丙二醛均高于营养不足地区。但在各调查点，未发现暴露的氟化物对人体有遗传毒性以及血浆中一般生化指标和微量元素与氟和营养水平有明显一致的规律性
According to the unified research design and method, the environmental fluorine level in four regions with different fluoride levels and nutritional status in four regions and the fluoride levels in different regions and the dietary nutrition, total fluoride intake, fluoride levels in more than 1,200 residents aged 40-60 years Poisoning and other epidemiological and biochemical indicators of a comprehensive investigation and analysis. The results showed that the detection rate of fluorosis in areas with high fluoride and undernutrition was significantly higher than those with normal fluoride content and confirmed that human nutrition status, especially calcium and protein, had a certain impact on the fluoride absorption and utilization. The survey found that: excessive intake of fluoride may reduce the body’s ability to scavenge free radicals; the same fluoride levels, normal diet plasma levels of plasma dismutase and malondialdehyde were higher than under-nourished areas. However, at each investigation point, there was no regularity of the genotoxicity of exposed fluoride on human body and the general biochemical indexes and trace elements in blood plasma and the level of fluoride and nutrition