目的　探讨肥大细胞在输卵管妊娠中的数量变化及其与血清性激素的关系。方法 :取输卵管妊娠时的输卵管及月经周期的增生期、分泌期和正常宫内早孕时的输卵管 ,常规石蜡切片 ,用甲苯胺蓝染色法显示肥大细胞 ;用酶免疫分析法检测输卵管妊娠患者、正常育龄未孕妇女 (增生期和分泌期 )及正常宫内早孕妇女血清雌二醇和孕酮水平。结果 :输卵管妊娠患者血清雌二醇和孕酮水平均高于正常育龄未孕妇女 (增生期和分泌期 ) ,低于正常宫内早孕妇女 ,四组间两两比较差异均有显著性 (P <0 0 5 ) ;肥大细胞主要分布于输卵管肌层 ,其数量变化为 :输卵管妊娠组较增生期和分泌期这两组均少 ,差异均有显著性 (P <0 0 5 ) ,而增生期和分泌期这两组肥大细胞数量变化不明显 ,差异无显著性 (P >0 0 5 ) ;两例正常宫内早孕时的输卵管壁肥大细胞数量明显比输卵管妊娠组多 ,与增生期和分泌期这两组比较 ,肥大细胞数量变化不明显。结论 :1 人输卵管壁内肥大细胞的数量不受血清性激素水平的影响。 2 输卵管妊娠时肥大细胞数量减少 Objective To investigate the changes of mast cells in tubal pregnancy and its relationship with serum sex hormones. Methods: The fallopian tubes during the tubal pregnancy and the proliferative phase of the menstrual cycle, secretory phase and normal intrauterine pregnancy during the fallopian tubes, paraffin sections, with toluidine blue staining showed mast cells; enzyme immunoassay detection of tubal pregnancy patients, Normal women of childbearing age (proliferative and secretory phase) and normal intrauterine pregnancy women serum estradiol and progesterone levels. Results: The serum levels of estradiol and progesterone in patients with tubal pregnancy were significantly higher than those in normal pregnant women (proliferative stage and secretory stage) and lower than those in normal intrauterine pregnant women. The differences among the four groups were significant (P < The number of mast cells was mainly distributed in the tubal muscle layer. The number of mast cells in the tubal pregnancy group was less than that in the proliferative and secretory phases (P <0.05), while the proliferative phase (P> 0.05). The number of tubal wall mast cells in two cases of normal intrauterine pregnancy was obviously more than that of tubal pregnancy group, and the number of proliferative phase and secretion The two groups compared the period, the number of mast cells did not change significantly. Conclusion: The number of mast cells in the wall of one fallopian tube is not affected by serum sex hormones. 2 tubal pregnancy when the number of mast cells decreased