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本研究临床观察了胃尔康片对慢性萎缩性胃炎（ＣＡＧ）脾胃阴虚证的疗效。采用单盲法，对照药为维酶素。两组服药前后作纤维胃镜及病理活检。结果：治疗组３２３例中临床治愈１１８例（３６．５３％），显效１３５例（４１．７９％），有效６１例（１８．８９％），无效９例（２．７９％）；总有效率９７．２１％。对照组１０５例中显效８例（７．６２％），有效３５例（３３．３３％），无效６２例（５９．０５％）；总有效率４０．９５％。两组比较差异有显著性意义（ｘ２＝１６６．６，Ｐ＜０．０１）。病理检查显示肠上皮化生及不典型增生消失率治疗组均优于对照组（ｐ＜０．０１）。实验研究采用Ｗｉｓｔａｒ大鼠作ＣＡＧ模型及胃尔康的长期毒性试验，应用狗作胃尔康对胃肠电活动影响的试验。结果：胃尔康长期毒性试验表明，高剂量（１０ｇ／ｋｇ）组有轻度兴奋反应，中（５ｇ／ｋｇ）、低（１ｇ／ｋｇ）剂量组无毒副反应。动物ＣＡＧ模型试验表明，胃尔康有显著的消炎、强壮、健脾作用外，还有促进萎缩腺体再生和修复之功效。对狗胃肠电活动影响，主要起兴奋作用，优于吗丁啉（Ｐ＜０．０５）。
This study clinical observation of Weier Kang Tablets chronic atrophic gastritis (CAG) the effect of the spleen and stomach yin deficiency. The single-blind method, the control drug for the enzyme enzyme. Two groups before and after taking fiber endoscopy and biopsy. Results: Among the 323 cases in the treatment group, 118 cases (36.53%) were clinically cured, 135 cases (41.79%) were markedly cured, 61 cases (18.89%) were effective, 9 cases (2.79%) were ineffective, Efficiency of 97.21%. The control group of 105 cases markedly effective in 8 cases (7.62%), effective in 35 cases (33.33%), ineffective in 62 cases (59.05%); the total efficiency of 40.95%. There was significant difference between the two groups (x2 = 166.6, P <0.01). Pathological examination showed intestinal metaplasia and dysplasia disappearance rate of the treatment group were better than the control group (p <0.01). Experimental study Wistar rats for CAG model and long-term toxicity test of Weier Kang, the application of dog as Weier Kang on gastrointestinal electrical activity test. Result: Weilekang long-term toxicity test showed mild irritant response in high dose (10g / kg) group and non-toxic side effects in medium dose (5g / kg) and low dose (1g / kg) Animal CAG model tests show that, Weier Kang significant anti-inflammatory, strong, spleen, but also to promote atrophy gland regeneration and repair effect. The gastrointestinal electrical activity of dogs, mainly excited, better than domperidone (P <0.05).