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目的:比较陕西地区人群中非酒精性脂肪肝(NAFLD)患者与正常人群肝脂肪酶(HLG)-514C/T多态性分布差异,探讨其与NAFLD发病易感性关系。方法:选取NAFLD患者96例及正常对照组98例,用非变性聚丙烯酰胺凝胶电泳进行基因多态位点检测HLG-514位点基因型,并测量其体重指数、腰臀比、血压、胆固醇、高密度脂蛋白、低密度脂蛋白、甘油三酯、空腹血糖指数。结果:正常对照组HLG-514CC、CT、TT基因型分别是26.5%、59.2%、14.2%,NAFLD组31.3%、63.5%、5.2%,两组CC基因型频率和C等位基因频率比较有统计学差异。结论:肝脂肪酶-514C/T以杂合子C/T基因型所占的百分比高,其基因多态性与陕西NAFLD患者发病有关。
Objective: To compare the distribution of hepatic lipase (HLG) -514C / T polymorphism between non-alcoholic fatty liver disease (NAFLD) patients and normal population in Shaanxi Province and to explore its relationship with the susceptibility to NAFLD. Methods: Ninety-six patients with NAFLD and 98 normal controls were enrolled. Genotypes of HLG-514 loci were detected by non-denaturing polyacrylamide gel electrophoresis. Body mass index, waist-hip ratio, blood pressure, Cholesterol, High Density Lipoprotein, Low Density Lipoprotein, Triglyceride, Fasting Glycemic Index. Results: The genotypes of HLG-514CC, CT and TT in normal control group were 26.5%, 59.2% and 14.2%, respectively. The frequency of CC genotype and C allele in NAFLD group were 31.3%, 63.5% and 5.2% Statistical differences. CONCLUSION: Hepatic lipase-514C / T has a high percentage of heterozygous C / T genotypes, and its gene polymorphism is associated with the onset of NAFLD in Shaanxi.