目的:观察2型糖尿病合并脂肪肝患者中是否存在胰岛素抵抗。方法:对66例2型糖尿病合并脂肪肝患者及129例2型糖尿病不伴有脂肪肝患者进行空腹血糖、餐后2h血糖、空腹血浆胰岛素(FINS)及C肽(C-P)、餐后2h血浆胰岛素(2hINS)及C肽(2hC-P)、血脂水平及身高、体重等的测定,计算体重指数(BMI)及胰岛素抵抗指数(IRI)。结果:2型糖尿病伴有脂肪肝组的FINS,C-P水平,BMI,IRI均明显高于不伴有脂肪肝组(P<0.05)。结论:2型糖尿病合并脂肪肝患者存在明显胰岛素抵抗及超重。 Objective: To observe the presence of insulin resistance in type 2 diabetic patients with fatty liver. Methods: The fasting blood glucose, postprandial 2h blood glucose, fasting plasma insulin (FINS) and C-peptide (CP), postprandial plasma 2h Insulin (2hINS) and C-peptide (2hC-P), blood lipid level and height, weight and other measurements, body mass index (BMI) and insulin resistance index (IRI) were calculated. Results: FINS and C-P levels, BMI and IRI in type 2 diabetic patients with fatty liver were significantly higher than those without fatty liver (P <0.05). Conclusion: Patients with type 2 diabetes mellitus and fatty liver have obvious insulin resistance and overweight.