细菌产物可以诱发肝硬化的主张已长期为临床医生和实验学者所坚持。在1954年,Luckey及其同工揭示饮食诱发老鼠的肝坏死在无菌条件下可以避免。嗣后又有报告,缺乏胆硷诱发的肝硬化可经投用不易吸收的抗菌素得以预防,而这种保护作用又可因饮用含纯净内毒素的水而丧失。此后令人信服的实验证据日见增多,表明肠原性内毒素不仅加重肝脏损害,而且对已有肝损害者尚可引起全身性并发症,如DIC。 The claim that bacterial products can induce cirrhosis has long been advocated by clinicians and experimenters. In 1954, Luckey and coworkers revealed that diet-induced liver necrosis was averted in aseptic conditions. It was subsequently reported that the lack of choline-induced cirrhosis can be prevented by administering an antibiotic that is not readily absorbed, and this protective effect can be lost by drinking pure endotoxin-containing water. Increasing evidence of convincing evidence since then indicates that enteric endotoxin not only exacerbates liver damage but also causes systemic complications such as DIC for those who have had liver damage.