增生性玻璃体视网膜病变 (proliferativevitreoretinopathy ,PVR)是在孔源性视网膜脱离或视网膜脱离复位术后 ,由于视网膜色素上皮细胞 (RPE)及神经胶质细胞的增生和收缩 ,造成牵拉性视网膜脱离的病变。PVR的病理特征是细胞增生 ,RPE一旦开始增殖 ,就产生细胞生长因子 ,而这些细胞生长因子反过来又刺激细胞增殖。PVR的过程有多种细胞及因子的参与 ,参与PVR增生的细胞主要是RPE和视网膜神经胶质细胞 ;涉及PVR的生长因子有 :PDGF、EGF、VEGF、TGF、FGF、IGF、HGF等 Proliferative vitreoretinopathy (PVR) is a type of rhegmatogenous retinal detachment after rhegmatogenous retinal detachment or retinal detachment and resection, due to the proliferation and contraction of retinal pigment epithelial cells (RPE) and glial cells . The pathological feature of PVR is cell proliferation. Once RPE begins to proliferate, it produces cell growth factors, which in turn stimulate cell proliferation. The process of PVR involves many kinds of cells and factors. The cells involved in PVR proliferation are mainly RPE and retinal glial cells. The growth factors involved in PVR are: PDGF, EGF, VEGF, TGF, FGF, IGF, HGF, etc.