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本文对51例男性化妇女测定了睾丸酮、游离睾丸酮、雄烯二酮、17α-羟孕酮、硫酸脱氢表雄酮(DHAS)、性激素结合蛋白(SHBG)、雄甾烷二醇和游离雄激素指数(FAI)。男性化妇女伴有高雄激素者92％有明显的SHBG值降低,且FAI明显升高,雄烯二酮和17α-羟孕酮无明显变化,17例雄甾烷二醇值均高于正常,且与睾丸酮和游离睾丸酮有密切相关性(γ=0.78,γ=0.80)。对于女性男性化病例的诊断除测定睾丸酮和DHAS外,还应测定SHBG和FAI。
In this study, 51 male subjects were tested for testosterone, free testosterone, androstenedione, 17α-hydroxyprogesterone, DHAS, SHBG, androstanediol and free androgen Index (FAI). 92% of masculine women with hyperandrogenism had a significant reduction of SHBG value and FAI was significantly increased, androstenedione and 17α-hydroxy progesterone no significant change in 17 cases of androstanediol values were higher than normal, And with testosterone and free testosterone are closely related (γ = 0.78, γ = 0.80). Diagnosis of female masculine cases In addition to determining testosterone and DHAS, SHBG and FAI should also be determined.