目的:探讨复方丹参片防治冠心病的可能机制。方法:高血脂大鼠采用球囊损伤法建立动脉损伤模型,观察复方丹参片对大鼠血脂、主动脉病理学等指标的影响。结果:复方丹参片可降低内膜与中膜比值、减轻主动脉病理性斑块的形成,但对血脂含量无明显影响。结论:复方丹参片防治冠心病可能与其抗动脉内膜损伤等作用有关。 Objective: To investigate the possible mechanism of compound Danshen tablets in preventing and treating coronary heart disease. Methods: The model of arterial injury was established by balloon injury in hyperlipidemic rats. The effects of Fufang Danshen Tablet on the blood lipid and aortic pathology were observed. Results: Salvia miltiorrhiza tablet could reduce the ratio of intima to media and alleviate the formation of aortic pathological plaque, but had no obvious effect on the content of blood lipid. Conclusion: The prevention and treatment of coronary heart disease with compound Danshen Tablets may be related to the anti-arterial intimal injury.