由于 N-乙酰化酶的活性可影响血浆药物浓度,因而化疗药物疗效与 N-乙酰化酶的乙酰化率有密切关系。作者在麻风流行区对不同麻风病人的乙酰化作用以及其在氨苯砜(DDS)耐药的发生中可能具有的影响进行了研究。27例成年患者,16例经鼠足垫试验证明对 DDS 耐药,其余对 DDS 敏感。试验前,病人住院并停药5天,而后给 DDS 100mg,投药前和投药后3、6、24小时采血标本。每0.5ml Because the activity of N-acetylase can affect plasma drug concentration, the curative effect of chemotherapeutic drugs is closely related to the acetylation rate of N-acetylase. The authors studied the possible role of acetylation in leprosy patients in different leprosy patients and their possible role in the development of dapsone (DDS) resistance. Twenty-seven adult patients, 16 rats footpad test proved resistant to DDS, the rest of the DDS-sensitive. Before the trial, the patient was hospitalized and stopped for 5 days, then given DDS 100mg, before administration and 3,6,24 hours after administration of blood samples. Every 0.5ml