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目的探究新活素(冻干重组人脑利钠肽)对急性心肌梗死患者的血管内皮功能的影响,为临床提供理论参考。方法 80例急性心肌梗死患者,随机分为对照组和研究组,各40例。对照组行常规药物治疗,研究组在常规治疗的基础上加用新活素治疗。对比分析两组患者的肱动脉内皮依赖性舒张功能(FMD)变化及血清一氧化氮(NO)和内皮素1的水平情况。结果治疗前两组患者FMD情况比较,差异无统计学意义(P>0.05);而治疗后,研究组患者的FMD情况改善显著优于对照组,差异有统计学意义(P<0.05)。治疗后,研究组患者的血清NO水平(45.01±4.78)μmol/L和内皮素1水平(73.65±20.67)ng/L改善显著,分别优于对照组的(37.21±4.89)μmol/L、(81.52±22.33)ng/L,差异有统计学意义(P<0.05)。结论对急性心肌梗死患者使用新活素,可有效增加患者血清NO含量,降低内皮素1水平,有效改善患者的血管内皮功能。
Objective To investigate the effect of neomycin (freeze-dried recombinant human brain natriuretic peptide) on vascular endothelial function in patients with acute myocardial infarction and to provide a theoretical reference for clinical practice. Methods Eighty patients with acute myocardial infarction were randomly divided into control group and study group, 40 cases in each. The control group received conventional drug therapy, and the study group added neomycin on the basis of routine treatment. The changes of brachial artery endothelium-dependent vasodilation (FMD) and the levels of serum nitric oxide (NO) and endothelin-1 were compared between the two groups. Results There was no significant difference in FMD between two groups before treatment (P> 0.05). After treatment, the improvement of FMD in study group was significantly better than that in control group (P <0.05). After treatment, the serum NO levels (45.01 ± 4.78) μmol / L and the endothelin 1 levels (73.65 ± 20.67) ng / L in the study group were significantly improved, which were significantly higher than those in the control group (37.21 ± 4.89 μmol / L, 81.52 ± 22.33) ng / L, the difference was statistically significant (P <0.05). Conclusions The use of new activin in patients with acute myocardial infarction can effectively increase the serum NO content, reduce the level of endothelin 1 and effectively improve the endothelial function of patients.