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本文研究了73例肾移植后病人,除了检测血C反应蛋白浓度外,同时测定了尿C反应蛋白.尿C反应蛋白测定采用免疫光度法(Immunoluminomet rischen Assay),其临界值为6μg/l。结果表明,36例经组织学证实有排斥危象和21例细菌培养阳性病人,尿中C反应蛋白阳性、相反无排斥反应或因环孢素霉素毒性反应及单纯巨细胞病毒感染病人,其尿C反应蛋白为阴性。认为血和尿C反应蛋白的比值,视为-敏感性监测排斥反应(CRPs/CRPu<1)和判断细菌感染(CRPsl)的指标。因此,尿C反应蛋白可作为一种特殊尿蛋白诊断,有利于肾移植后的早期监测,并与血C反应蛋白配合,可鉴别肾移植后的严重并发症。
In this study, 73 renal transplant recipients were enrolled in this study. Urinary C-reactive protein was also measured in addition to blood C-reactive protein. Urine C-reactive protein was assayed by Immunoluminomet rischen Assay with a cutoff of 6 μg / l. The results showed that 36 cases of histologically confirmed rejection crisis and 21 cases of bacterial culture positive patients urine C-reactive protein positive, on the contrary no rejection or cyclosporine toxicity and cytomegalovirus infection alone, the patient Urinary C-reactive protein is negative. The ratio of blood to urine C-reactive protein was considered as an indicator of sensitivity to monitor rejection (CRPs / CRPu <1) and to determine bacterial infection (CRPs <1). Therefore, urine C-reactive protein can be used as a special urine protein diagnosis, is conducive to early monitoring after renal transplantation, and with blood C-reactive protein, can identify the serious complications after kidney transplantation.