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四氯化碳经口中毒动物试验表明:急性中毒引起肝细胞膜脂质过氧化反应,P-450降低,SGPT 和肝甘油三脂增高,并且确认脂质过氧化是四氯化碳中毒重要起始反应;慢性中毒阈剂量为0.2mg/kg,形态学上的改变为肝细胞脂肪变、坏死和增生、亚细胞结构粗面内质网颗粒脱落,空泡反应,最大无作用剂量为0.02mg/kg,换算成浓度值为0.4mg/L,加上必要的安全系数,建议水源水中四氯化碳最高容许浓度为0.004mg/L。
CTC oral toxicity animal experiments show that: acute poisoning caused by liver cell membrane lipid peroxidation, P-450 decreased, SGPT and hepatic triglycerides increased, and confirmed that lipid peroxidation is an important start of carbon tetrachloride poisoning Reaction; Chronic poisoning threshold dose of 0.2mg / kg, morphological changes of fatty liver cells, necrosis and hyperplasia, subcellular structure rough endoplasmic reticulum particles shedding, vacuolization reaction, the maximum non-effect dose of 0.02mg / kg, converted to a concentration value of 0.4mg / L, with the necessary safety factor, it is recommended that the maximum allowable concentration of carbon tetrachloride in water of source is 0.004mg / L.